About our research group/lab
Our research
Why was this group formed?
In order to achieve better quality of life of patients with Atopic Dermatitis we aim to unravel the underlying mechanisms of the disease, understand its heterogeneity, and to improve treatment.
What is the overall aim?
Our mission is to develop novel ways to better characterize Atopic Dermatitis patients by integrating clinical, serological, cellular and molecular biomarkers. This will lead to a better understanding of disease mechanisms and contribute to precision medicine.
What type of research do you focus on in this group?
Although it is well known that Atopic Dermatitis is highly heterogeneous and many attempts have been made to define clinical phenotypes, science so far has not succeeded in establishing generally accepted definitions of clinical phenotypes.Our research focuses on the underlying mechanism that differentiate patients with different endophenotypes, to better understand the disease, find new targets for treatment, and to predict treatment response.
Our projects
- Predictive biomarkers in atopic dermatitis
- Severity biomarkers for measuring disease severity in atopic dermatitis
- New treatments for atopic dermatitis (clinical trials with biologics and small molecule inhibitors)
- Integration of clinical, serological, cellular and molecular data to better understand disease pathogenesis
Key Publications
de Wijs LEM, Bosma AL, Erler NS, Hollestein LM, Gerbens LAA, Middelkamp-Hup MA, Kunkeler ACM, Nijsten TEC, Spuls PI, Hijnen DJ. Effectiveness of dupilumab treatment in 95 patients with atopic dermatitis: daily practice data. Br J Dermatol. 2019.
de Wijs LEM, Nguyen NT, Kunkeler ACM, Nijsten T, Damman J, Hijnen DJ. Clinical and histopathological characterization of paradoxical head and neck erythema in patients with atopic dermatitis treated with dupilumab: a case series. Br J Dermatol. 2019.
Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, Nierkens S, Giovannone B, Csomor E, Sellman BR, Mustelin T, Ph.D., Sleeman, de Bruin-Weller MS, Herath A, Drylewicz J, May RD, Hijnen DJ, Moving towards endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis, J Allergy Clin Immunol. 2017 Sep;140(3):730-737
Collaborations
- Department of Immunology
- Department of Biomics
- Department of Bioinformatics/ Biostatistics
- Department of Pathology
Our team
Linde de Wijs, PhD student
Jill Olydam, PhD student
Katharina Bartelmann, MD
Luba Pardo Cortes, MD, PhD
Suzanne Pasmans, MD, PhD
Loes Zandwijk-Hollestein, PhD
Jeffrey Damman, MD, PhD
DirkJan Hijnen, MD, PhD
