About S. (Soheil) Yousefi
Introduction
My PhD project concerns the multi-omics data integration of non-coding regulatory elements involved in brain development. As a bioinformatician, I also closely collaborate with my colleagues in the lab, and analyze various next-generation sequencing data. These activities, together with ongoing experimental approaches in our lab, will characterize the role of enhancers in neurodevelopmental disorders and will enable a new functional-based approach in clinical genetics diagnostics.
Field(s) of expertise
Bioinformatics
Education and career
PhD. Animal Genetics and Biotechnology at the Ferdowsi University of Mashhad. Thesis: “Epitope prediction and antigenicity evaluation of Brucella melitensis Omp31 and Omp25 antigens”.
Publications
Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.
Elena Perenthaler, Anita Nikoncuk, Soheil Yousefi, Woutje M Berdowski, Maysoon Alsagob, Ivan Capo, Herma C van der Linde, Paul van den Berg, Edwin H Jacobs, Darija Putar, Mehrnaz Ghazvini, Eleonora Aronica, Wilfred F J van IJcken, Walter G de Valk, Evita Medici-van den Herik, Marjon van Slegtenhorst, Lauren Brick, Mariya Kozenko, Jennefer N Kohler, Jonathan A Bernstein, Kristin G Monaghan, Amber Begtrup, Rebecca Torene, Amna Al Futaisi, Fathiya Al Murshedi, Renjith Mani, Faisal Al Azri, Erik-Jan Kamsteeg, Majid Mojarrad, Atieh Eslahi, Zaynab Khazaei, Fateme Massinaei Darmiyan, Mohammad Doosti, Ehsan Ghayoor Karimiani, Jana Vandrovcova, Faisal Zafar, Nuzhat Rana, Krishna K Kandaswamy, Jozef Hertecant, Peter Bauer, Mohammed A AlMuhaizea, Mustafa A Salih, Mazhor Aldosary, Rawan Almass, Laila Al-Quait, Wafa Qubbaj, Serdar Coskun, Khaled O Alahmadi, Muddathir H A Hamad, Salem Alwadaee, Khalid Awartani, Anas M Dababo, Futwan Almohanna, Dilek Colak, Mohammadreza Dehghani, Mohammad Yahya Vahidi Mehrjardi, Murat Gunel, A Gulhan Ercan-Sencicek, Gouri Rao Passi, Huma Arshad Cheema, Stephanie Efthymiou, Henry Houlden, Aida M Bertoli-Avella, Alice S Brooks, Kyle Retterer, Reza Maroofian, Namik Kaya, Tjakko J van Ham, Tahsin Stefan Barakat. (2020). Acta Neuropathol. 2020 Mar;139(3):415-442. doi: 10.1007/s00401-019-02109-6.
Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development.
Elena Perenthaler, Soheil Yousefi, Eva Niggl, and Tahsin Stefan Barakat. (2019). Front Cell Neurosci. 2019 Jul 31;13:352. doi: 10.3389/fncel.2019.00352.
A SNP panel for identification of DNA and RNA specimens.
Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van 't Hof, Maarten van Iterson, Daria V Zhernakova, Annique Claringbould, Lude Franke, Leen M 't Hart, Roderick C Slieker, Amber van der Heijden, Peter de Knijff. (2018). BMC Genomics. 2018 Jan 25;19(1):90. doi: 10.1186/s12864-018-4482-7.
Evaluation of immune responses induced by polymeric OMP25-BLS Brucella antigen.
Soheil Yousefi, Tooba Abbassi-Daloii, Mohammad Hadi Sekhavati, Mojtaba Tahmoorespur. (2018). Microb Pathog. 2018 Feb;115:50-56. doi: 10.1016/j.micpath.2017.12.045.
Microbial Pathogenesis. 2018 Impact of heat shock protein 60KD in combination with outer membrane proteins on immune response against Brucella melitensis.
Tooba Abbassi-Daloii, Soheil Yousefi, Mohammad Hadi Sekhavati, Mojtaba Tahmoorespur. (2018). APMIS. 2018 Jan;126(1):65-75. doi: 10.1111/apm.12778.
An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites.
Tooba Abbassi-Daloii, Soheil Yousefi, Eleonora de Klerk, Laurens Grossouw, Muhammad Riaz, Peter A C 't Hoen, Vered Raz. (2017). NPJ Aging Mech Dis. 2017 Apr 7;3:6. doi: 10.1038/s41514-017-0007-x. eCollection 2017.
