P.C.M.S. (Paul) Verhagen MD

My name is Paul Verhagen. Since 1999 I have worked in Erasmus MC. I have been involved in several clinical studies and in preclinical research.

Focus of research:

• Prostate cancer,
• Renal cancer.

• Renal cancer.
• Prostate cancer.

• 1974 - 1980: Gymnasium ß, Jacob Roelandslyceum, Boxtel, the Netherlands, cum laude.
• 1980 - 1981: Hamline University, St Paul, MN, USA. Major: Biology. Exchange program of the Netherlands American Commission for Educational Exchange (NACEE), Amsterdam, the Netherlands.
• 1981 - 1989: Medical study, Catholic University Nijmegen, the Netherlands, Bachelors; cum laude.

Urology training

1992 - 1997: University Hospital Utrecht, the Netherlands, Prof. dr. T.A. Boon, MD, PhD, urologist.

Ph. D. Thesis

2005: Genetic analyses of clinical prostate cancer. Promotors: prof. dr. ir. J. Trapman and prof. dr. C.H. Bangma, Erasmus MC, Rotterdam, the Netherlands. 

Co-promotor

2011: Prognostic implications of important genetic alterations in prostate cancer. J. Boormans.

Clinical research fellow Dutch Cancer Society/Koningin Wilhelmina Fonds

1998 - 1999: Supervisor Prof. dr. F.H. Schröder. In this fellowship visit to University of Utah Salt Lake City, Utah, USA, Study topic: Comparative genomic hybridization in familial prostate cancer. Prof. A.R. Brothman, Ph.D, department of cytogenetics.

Bosniak Classification for Complex Renal Cysts Reevaluated: A Systematic Review.
Ivo G Schoots, Keren Zaccai, Myriam G Hunink, Paul C M S Verhagen. (2017). J Urol. 2017 Jul;198(1):12-21. doi: 10.1016/j.juro.2016.09.160.

Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia.
Ling Oei, Anton H van den Meiracker, Edwin H G Oei, Adriaan Moelker, Geert J L H van Leenders, Berend Rikken, Paul Verhagen, Marian C Clahsen-van Groningen, Hans E van der Wiel. (2016). Case Reports Am J Med . 2016 Aug;129(8):e131-2.

De Bosniak-classificatie voor niercysten: tijd voor een volgende verandering? 
Romy E.D. Lamers, Kèren Zaccai, Ivo G. Schoots & Paul C.M.S. Verhagen. (2016). Ned Tijdschrift voor Urologie 2016, Volume 6, Issue 1, 2-14.

Intermittent versus continuous cyproterone acetate in bone metastatic prostate cancer: results of a randomized trial. 
Paul C M S Verhagen, Mark F Wildhagen, Annet M Verkerk, Egils Vjaters, Hembo Pagi, Leonhard Kukk, Dejan Bratus, Richard Fiala, Chris H Bangma, Fritz H Schröder, Gerald H J Mickisch. (2014). World J Urol. 2014 Oct;32(5):1287-94.

Prostate cancer: ESMO Consensus Conference Guidelines 2012. 
A Horwich, J Hugosson, T de Reijke, T Wiegel, K Fizazi, V Kataja, Panel Members; European Society for Medical Oncology. (2013). Ann Oncol . 2013 May;24(5):1141-62.

Long-term outcome of kidney transplantation in patients with a urinary conduit: a case-control study. 
Inez K B Slagt 1, Jan N M Ijzermans, Mustafa Alamyar, Paul C M S Verhagen, Willem Weimar, Joke I Roodnat, Türkan Terkivatan. (2013). Int Urol Nephrol. 2013 Apr;45(2):405-11.

Management van lymfekliergemetastaseerd prostaatcarcinoom: rol voor chirurgie? 
P. C. M. S. Verhagen, L. Collette & C. H. Bangma. (2012). Tijdschrift voor Urologie volume 2, pages29–37(2012).

Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911). 
Michel Bolla, Hein van Poppel, Bertrand Tombal, Kris Vekemans, Luigi Da Pozzo, Theo M de Reijke, Antony Verbaeys, Jean-François Bosset, Roland van Velthoven, Marc Colombel, Cees van de Beek, Paul Verhagen, Alphonsus van den Bergh, Cora Sternberg, Thomas Gasser, Geertjan van Tienhoven, Pierre Scalliet, Karin Haustermans, Laurence Collette, European Organisation for Research and Treatment of Cancer, Radiation Oncology and Genito-Urinary Groups. (2012). Lancet. 2012 Dec 8;380(9858):2018-27.

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). 
Eric A Klein, Ian M Thompson Jr, Catherine M Tangen, John J Crowley, M Scott Lucia, Phyllis J Goodman, Lori M Minasian, Leslie G Ford, Howard L Parnes, J Michael Gaziano, Daniel D Karp, Michael M Lieber, Philip J Walther, Laurence Klotz, J Kellogg Parsons, Joseph L Chin, Amy K Darke, Scott M Lippman, Gary E Goodman, Frank L Meyskens Jr, Laurence H Baker. (2011). JAMA. 2011 Oct 12;306(14):1549-56.

Current vaccination strategies for prostate cancer.
Steven Joniau, Per-Anders Abrahamsson, Joaquim Bellmunt, Carl Figdor, Freddie Hamdy, Paul Verhagen, Nicholas J Vogelzang, Manfred Wirth, Hendrik Van Poppel, Susanne Osanto. (2012). Eur Urol. 2012 Feb;61(2):290-306.

Surgical Anatomy of the 10th and 11th Intercostal, and Subcostal Nerves: Prevention of Damage During Lumbotomy. 
Teunettevan der Graaf Paul C.M.S.Verhagen Anton L.A.Kerver Gert-Jan Kleinrensink. (2011). J Urol. 2011 Aug;186(2):579-83.

Does local treatment of the prostate in advanced and/or lymph node metastatic disease improve efficacy of androgen-deprivation therapy? A systematic review. 
Paul C M S Verhagen, Fritz H Schröder, Laurence Collette, Chris H Bangma. (2010). Eur Urol. 2010 Aug;58(2):261-9.

Diagnostic value of urinary dysmorphic erythrocytes in clinical practice.
Meindert J Crop, Yolanda B de Rijke, Paul C M S Verhagen, Karlien Cransberg, Robert Zietse. (2010). Nephron Clin Pract. 2010;115(3):c203-12.

E17K substitution in AKT1 in prostate cancer. 
J L Boormans, H Korsten, A C J Ziel-van der Made, G J L H van Leenders, P C M S Verhagen, and J Trapman. (2010). Br J Cancer. 2010 May 11; 102(10): 1491–1494.

Kidney and urinary tract imaging: triple-bolus multidetector CT urography as a one-stop shop--protocol design, opacification, and image quality analysis. 
Maka Kekelidze, Roy S Dwarkasing, Marcel L Dijkshoorn, Karolina Sikorska, Paul C M S Verhagen, Gabriel P Krestin. (2010). Radiology. 2010 May;255(2):508-16.

Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer. 
Karin G Hermans, Joost L Boormans, Delila Gasi, Geert J H L van Leenders, Guido Jenster, Paul C M S Verhagen, Jan Trapman. (2009). Clin Cancer Res. 2009 Oct 15;15(20):6398-403.

Expression of the androgen-regulated fusion gene TMPRSS2-ERG does not predict response to endocrine treatment in hormone-naïve, node-positive prostate cancer. 
Joost L Boormans, Karin G Hermans, Angelique C J Ziel-van der Made, Geert J H L van Leenders, Mark F Wildhagen, Laurence Collette, Fritz H Schröder, Jan Trapman, Paul C M S Verhagen. (2010). Eur Urol. 2010 May;57(5):830-5.

Words of wisdom. Re: Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. 
Paul C M S Verhagen. (2009). Eur Urol. 2009 May;55(5):1239-40.

Predicting the future in castration-resistant prostate cancer. 
Paul Verhagen. (2009). REFLECTION AND REACTION| VOLUME 10, ISSUE 3, P201-202, MARCH 01, 2009

Histopathological characteristics of lymph node metastases predict cancer-specific survival in node-positive prostate cancer.
Joost L Boormans, Mark F Wildhagen, Chris H Bangma, Paul C Verhagen, Geert J van Leenders BJU Int. 2008 Dec;102(11):1589-93.

When to start cytotoxic therapy in asymptomatic patients with hormone refractory prostate cancer?
P Hamberg 1, P C M S Verhagen, R de Wit. (2008). Eur J Cancer. 2008 Jun;44(9):1193-7.

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. 
Robert J Motzer, Thomas E Hutson, Piotr Tomczak, M Dror Michaelson, Ronald M Bukowski, Olivier Rixe, Stéphane Oudard, Sylvie Negrier, Cezary Szczylik, Sindy T Kim, Isan Chen, Paul W Bycott, Charles M Baum, Robert A Figlin. (2007). N Engl J Med. 2007 Jan 11;356(2):115-24.

Tubular and interstitial nephrocalcinosis. 
Maxime T M Kummeling, Bas W D de Jong, Charlie Laffeber, Dirk-Jan Kok, Paul C M S Verhagen, Geert J L H van Leenders, Ron H N van Schaik, Christiaan S van Woerden, Anja Verhulst, Carl F Verkoelen. (2007). J Urol. 2007 Sep;178(3 Pt 1):1097-103.

The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion.
P C M S Verhagen 1, P W van Duijn, K G L Hermans, L H J Looijenga, R J H L M van Gurp, H Stoop, T H van der Kwast, J Trapman. (2006). J Pathol. 2006 Apr;208(5):699-707.

Percutaneous nephrolithotomy for treating renal calculi in children. 
Joost L Boormans, Jeroen R Scheepe, Carl F Verkoelen, Paul C M S Verhagen. (2005). BJU Int. 2005 Mar;95(4):631-4.

Preventing stone migration during percutaneous nephrolithotomy by using the stone cone.
Marij Smit, Paul C.M.S. Verhagen. (2004). First published: 25 August 2004.

Deletion of chromosomal region 6q14-16 in prostate cancer.
Paul C M S Verhagen, Karin G L Hermans, Mariel O Brok, Wytzke M van Weerden, Marcel G J Tilanus, Roel A de Weger, Tom A Boon, Jan Trapman. (2002). Int J Cancer. 2002 Nov 10;102(2):142-7.

Prognostic factors in localised prostate cancer with emphasis on the application of molecular techniques.
P C M S Verhagen, M G J Tilanus, R A de Weger, R J A van Moorselaar, J G van den Tweel, T A Boon. (2002). Eur Urol. 2002 Apr;41(4):363-71.

Eosinophilic cystitis. 
P C Verhagen, P G Nikkels, T P de Jong. (2001). Arch Dis Child. 2001 Apr;84(4):344-6.

Microdissection, DOP-PCR, and comparative genomic hybridization of paraffin-embedded familial prostate cancers. 
P C Verhagen, X L Zhu, L R Rohr, L A Cannon-Albright, S V Tavtigian, M H Skolnick, A R Brothman. (2000). Cancer Genet Cytogenet. 2000 Oct 1;122(1):43-8.

Blood and serum substances for markers of prostate cancer. 
C H Bangma, P C Verhagen. (2000). Microsc Res Tech. 2000 Dec 1;51(5):430-5.

SPECT detection of pulmonary artery branch obstruction from a migrated Gianturco coil. 
P C Verhagen, P P Van Rijk, T M Lock, J H Blom, B L Van Eck-Smit. (1992). Clin Nucl Med. 1992 Aug;17(8):676-7.

Pulmonary embolism after percutaneous embolization of left spermatic vein. 
P Verhagen, J M Blom, P P van Rijk, M T Lock. (1992). Eur J Radiol. 1992 Oct;15(3):190-2.

• 2009 - 2017: responsible for practical training laparoscopy for residents. This is an obligatory yearly program for residents in training for urology.
• 2012 - present: responsible for residents in training for urology Rotterdam region.
• 2013 - present: NVU committee for quality visitation.
• 2016 - present: NVU committee for visitation of training hospitals.