About Dr. C. W. E. (Carmen) Embregts
Introduction
Carmen Embregts (1989) is a postdoctoral researcher at the Viroscience department of the Erasmus MC. She received a PhD from the Wageningen University and Research in 2018 for her work on multi-platform vaccine development against Spring Viremia of Carp Virus and Koi Herpes Virus. Since 2018 she works within the Comparative Pathology and Pathogenesis group, where she started her own independent research line that focuses on unraveling immunosuppressive pathways and mechanisms of rabies virus (RABV).
Current research and interests
Her main research focuses on characterizing how, where, and when rabies virus suppresses the immune response, with a special interest on how RABV affects innate immune cells in the earliest moments of infection.
Other main fields of interest are the improvement or development/validation of serological tests for RABV and SARS-CoV-2 and characterization of the cytokine responses in SARS-CoV-2 patients and neuronal models.
Current research and interests
Her main research focuses on characterizing how, where, and when rabies virus suppresses the immune response, with a special interest on how RABV affects innate immune cells in the earliest moments of infection.
Other main fields of interest are the improvement or development/validation of serological tests for RABV and SARS-CoV-2 and characterization of the cytokine responses in SARS-CoV-2 patients and neuronal models.
Education and career
Carmen (1989) received a PhD from the Wageningen University and Research in 2018 for her work on multi-platform vaccine development against Spring Viremia of Carp Virus (SVCV) and Koi Herpes Virus, and characterizing of the innate and adaptive immune response after vaccination and during infection of carp. She was the first to describe a fully protective DNA vaccine against SVCV , and the first to describe a virus-specific T and B cell response in fish.
Publications
Key publications:
Embregts, C.W.E., Begeman, L., Voesenek, C.J., Martina, B.E.E., Koopmans, M.P.G., Kuiken, T., GeurtsvanKessel, C.H. (2021). Street RABV induces the cholinergic anti-inflammatory pathway in human monocyte-derived macrophages by binding to nAChr ɑ7. Frontiers in Immunology 12(378).
Embregts, C.W.E., Verstrepen, B., Langermans, J.A.M., Boszormenyi, K.P., Sikkema, R.S., de Vries, R.D., Hoffmann, D., Wernike, K., Smit, L.A.M., Rockx, B., Koopmans, M.P.G., Haagmans, B.L., Kuiken, T., GeurtsvanKessel, C.H. (2021). Evaluation of a multi-species SARS-CoV-2 surrogate virus neutralization test. OneHealth 13(100313)
Embregts, C.W.E., Rigaedeau, D., Veselý, T., Pokorova, D., Lorenzen, N., Petit, J., Houel, A., Dauber, M., Schütze, H., Boudinot, P., Wiegertjes, G.F., Forlenza, M. (2017). Intra-muscular DNA vaccination against SVCV induces full protection in carp and establishes a virus-specific B- and T-cell memory. Frontiers in Immunology 8(1340)
van Riel, D., Embregts, C.W.E., Sips, G.J., van den Akker, J.P.C., Endeman, H., van Nood, E., van Kampen, K., Molenkamp, R., Koopmans, M.P.G., van de Vijver, D., GeurtsvanKessel, C.H. (2020). Temporal kinetics of RNAemia and associated systemic cytokines in hospitalized COVID-19 patients. mSphere 6(3)
GeurtsvanKessel, C.H., Okba, N.M.A., Igloi, Z., Bogers, S., Embregts, C.W.E., Laksono, B.M., Leijten, L., Rokx, C., Rijnders, B., Rahamat-Langendoen, J., van den Akker, J.P.C., van Kampen, J.J.A., van der Eijk, A.A., van Binnendijk, R.S., Haagmans, B., Koopmans, M.P.G. (2020). An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nature Communications 11(3436), 2020.
Doornekamp, L., Embregts, C.W.E., Aron, G.I., Goeijenbier, S., van de Vijver, D.A.M.C., van Gorp, E.C.M., GeurtsvanKessel, C.H. (2020). Dried blood spot cards: A reliable sampling method to detect human antibodies against rabies virus. PLOS Neglected Tropical Diseases 14(10).
Complete overview of publications: https://scholar.google.nl/citations?hl=nl&user=m_501acAAAAJ&view_op=list_works&sortby=pubdate
