D. (Daniel) Bos, MD, PhD

Academic education and degrees:

Below is a selection of journal articles (complete list of references).

2024:
Brain artery diameters and risk of dementia and stroke. Alzheimer’s and Dementia.
Melgarejo JD, Gurel K, Compton CR, Liu M, Guzman V, Assuras S, Levin BE, Elkind MSV, Ikram MK, Kavousi M, Ikram MA, Wright C, Crivello F, Laurent A, Tzourio C, Vernooij MW, Rundek T, Zhang ZY, Bos D, & Gutierrez J.  Advance online publication. 2024.

Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study.
van den Beukel TC, Wolters FJ, Siebert U, Spiering W, Ikram MA, Vernooij MW, de Jong PA, & Bos D. Alzheimers & Dementia, 2024. 20(2), 869-879.

Progression of arterial calcifications: what, where, and in whom?
van der Toorn JE, Vernooij MW, Ikram MA, Kavousi M, & Bos, D. European Radiology. 2024. Advance online publication.

2023:
Risk of recurrent stroke in Rotterdam between 1990 and 2020: a population-based cohort study
Berghout BP, Bos D, Koudstaal PJ, Ikram MA, Ikram MK. 
The Lancet Regional Health - Europe. 2023;30 (5).

Intracranial Carotid Arteriosclerosis Mediates the Association Between Blood Pressure and Cerebral Small Vessel Disease
Melgarejo JD, Vernooij MW, Ikram MA, Zhang ZY, Bos D.
Hypertension. 2022.

Sex Differences in Carotid Atherosclerosis: A Systematic Review and Meta-Analysis
van Dam-Nolen DHK, van Egmond NCM, Koudstaal PJ, van der Lugt A, Bos D.
Stroke. 2022;54 (2), 315-326. doi: 10.1161/STROKEAHA.122.041046.

2022:
Research Aims in Clinical Medicine: Description, Identification, or Explanation
Bos D, Ikram MA.
World Neurosurg. 2022;161. 240-244.

Lipoprotein (a) is associated with the onset but not the progression of aortic valve calcification
Kaiser Y, van der Toorn JE, Singh SS, Zheng KH, Kavousi M, Sijbrands EJG, Stroes ESG, Vernooij MW, de Rijke YB, Boekholdt SM, Bos D.
European Heart Journal. 2022;43 (39), 3960-3967.

Morphological subtypes of intracranial internal carotid artery arteriosclerosis and the risk of stroke
Van Den Beukel TC, van der Toorn JE, Vernooij MW, Kavousi M, Akyildiz AC, de Jong PA, van der Lugt A, Ikram MK, Bos D.
Stroke. 2022;53 (4), 1339-1347.

2021:
Atherosclerotic Carotid Plaque Composition and Incident Stroke and Coronary Events.
Bos D, Arshi B, van den Bouwhuijsen QJA, Ikram MK, Selwaness M, Vernooij MW, Kavousi M, van der Lugt A.
J Am Coll Cardiol. 2021 Mar 23;77(11):1426-1435.

Advances in Multimodality Carotid Plaque Imaging: AJR Expert Panel Narrative Review. 
Bos D, van Dam-Nolen DHK, Gupta A, Saba L, Saloner D, Wasserman BA, van der Lugt A.
AJR Am J Roentgenol. 2021 Jan 13.

Association of White Matter Lesions and Outcome After Endovascular Stroke Treatment. 
Luijten SPR, Bos D, Compagne KCJ, Wolff L, Majoie CBLM, Roos YBWEM, van Zwam WH, van Oostenbrugge RJ, Dippel DWJ, van der Lugt A, van Es ACGM; MR CLEAN trial investigators. Neurology. 2021 Jan 19;96(3):e333-e342

2020:
Aortic Arch Calcification and the Risk of Cancer: A Population-Based Cohort Study. 
van der Toorn JE, van der Willik KD, Ruiter R, Vernooij MW, Stricker BHC, Schagen SB, Ikram MA, Kavousi M, Bos D.
Front Oncol. 2020 Sep 11;10:1700

Sex-specific distributions and determinants of thoracic aortic diameters in the elderly. 
Bons LR, Rueda-Ochoa OL, El Ghoul K, Rohde S, Budde RP, Leening MJ, Vernooij MW, Franco OH, van der Lugt A, Roos-Hesselink JW, Kavousi M, Bos D.
Heart. 2020 Jan;106(2):133-139.

Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study
Mujaj B, Bos D, Kavousi M, van der Lugt A, Staessen JA, Franco OH, Vernooij MW.
Eur J Endocrinol. 2020 Mar;182(3):343-350.

2019:
Disease Mechanisms and Therapeutic Implications”. 
Bos D, van der Toorn J, Licher S. Letter by Bos et al regarding article “Intracranial Atherosclerotic.
Stroke. 2019;50:e261.  

Intracranial arterial wall imaging: techniques, clinical applicability and future perspectives.
Arenillas J, Dieleman N, Bos D. 
Int J Stroke. 2019;14(6):564-573 

Vertebrobasilar artery calcification: Prevalence and risk factors in the general population
Van der Toorn J, Engelkes S, Ikram M, Ikram M, Vernooij M, Kavousi M, Bos D.
Atherosclerosis. 2019;286:46-52. 

2018:
Intracranial carotid artery calcification and effect of endovascular stroke treatment: a MR CLEAN subgroup analysis.
Compagne C, Clephas P, Majoie C, Roos Y, Berkhemer O, van Oostenbrugge R, van Zwam W, van Es A, Dippel D, van der Lugt A, Bos D. 
Stroke. 2018;49:2961-2968. 

Antithrombotic treatment is associated with intraplaque hemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study.
Mujaj B, Bos D, Muka T, van der Lugt A, Ikram M, Vernooij M, Stricker B, Franco O. 
Eur Heart J. 2018: 39:3369-3376. 

Prevalence and volume of intracranial carotid artery calcification from infancy to old age.
Kockelkoren R, de Vis J, de Jong P, Vernooij M, Mali W, Hendrikse J, Schiestl T, Pellikaan K, van der Lugt A, Bos D. 
JACC. 2018: 72: 582-584. 

2017:
The Revised Framingham Stroke Risk Profile in a Primary Prevention Population: The Rotterdam Study.
Bos D, Ikram M, Leening M, Ikram M. 
Circulation. 2017; 135: 2207-09. 

Epicardial Fat Volume and the Risk of Atrial Fibrillation in the General Population Free of Cardiovascular Disease: The Rotterdam Study. 
Bos D, Vernooij M, Shahzad R, Kavousi M, Hofman A, Van Walsum T, Deckers J, Ikram M, Heeringa J, Franco O, Van der Lugt A, Leening M.
JACC: Cardiovasc Imaging. 2017. pii: S1936-87831019-1. 

Intracranial Carotid Artery Calcification relates to recanalization and clinical outcome after mechanical thrombectomy.
Bos D*, Hernández-Pérez M*,  Dorado L, Pellikaan K, Vernooij M,  López-Cancio E, Pérez de la Ossa N, Gomis M, Castaño C, Munuera J, Puig J, Millán M, Dávalos A. 
Stroke. 2017; 48:342-347 

2016:
Liver fat is related to cardiovascular risk factors and subclinical vascular disease: the Rotterdam Study.
Bos D*, Wolff L*, Darwish Murad S, Franco O, Krestin G, Hofman A, Vernooij M, Van der Lugt A.
Eur Heart J Cardiovasc Imaging. 2016. Pii: jew174.

Heritability and genome-wide association analyses of intracranial carotid artery calcification: the Rotterdam Study.
Adams H, Ikram M, Vernooij M, Van Dijk A, Hofman A, Uitterlinden A, Van Duijn C, Koudstaal P, Franco O, Van der Lugt A, Bos D. 
Stroke. 2016; 47:912-917.

Prevalence, clinical management and natural course of incidental findings on brain MRI: the population-based Rotterdam Scan Study.
Bos D, Poels M, Adams H, Akoudad S, Cremer L, Zonneveld H, Hoogendam Y, Verhaaren B, Verlinden V, Verbruggen J, Peymani A, Hofman A, Krestin G, Vincent A, Feelders R, Koudstaal P, Van der Lugt A, Ikram M, Vernooij M. 
Radiology. 2016; 160218.

2015:
The Rotterdam Scan Study: design update 2016 and main findings.
Ikram MA,  Van der Lugt A, Niessen W, Koudstaal P, Krestin G, Hofman A, Bos D, Vernooij M. 
Eur J Epid. 2015; 30:1299-1315.

Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality: the Rotterdam Study. 
Bos D, Leening M, Kavousi M, Hofman A, Franco O, Van der Lugt A, Vernooij M, Ikram M. 
Circ Cardiovasc Imaging. 2015; Dec. pii: e003843.

Epicardial fat volume is related to atherosclerotic calcification in multiple vessel beds.
Bos D, Shahzad R, Van Walsum T, Van Vliet L, Franco O, Hofman A, Niessen W, Vernooij M, Van der Lugt A. 
Eur Heart J Cardiovasc Imaging. 2015; 16:1264-1269.

2014:
Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline.
Bos D, Vernooij M, de Bruijn R, Koudstaal P, Hofman A, Franco O, Van der Lugt A, Ikram M. 
Alzheimers Dement. 2014; 11:639-47.e1.

Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study.
Bos D, Portegies M, Van der Lugt A, Bos M, Koudstaal P, Hofman A, Krestin G, Franco O, Vernooij M, Ikram M.
JAMA Neurol. 2014; 71:405-411.

Specific highlights of my teaching activities include the following. First, since 2016, I am  giving one of the opening lectures of the prestigious Junior Med School-programme for talented high school students that are interested in studying Medicine and performing scientific research. Second, since 2016, I am part of the teaching staff of the summer course entitled “Study design in Clinical Epidemiology” in the Master of Public Health-programme at the Harvard School of Public Health in Boston. Third, since 2018, I have become part of the core staff of the course “Clinical translation of Epidemiology” which is part of the Master of Science-programme provided by the Netherlands Institute of Health Sciences.