DURABLE

Project period: 01/02/2023 - 31-/01/2027  

Outbreaks of infectious diseases are increasing due to multiple local and global interaction changes disrupting the fragile balance of the complex human-animal-environment ecosystem. The increased frequency and complexity of health threats require a different, unified form of preparedness and a coordinated, fast, reliable and effective emergency response.

DURABLE is a tailored solution to this recognized need - a strong network of world-class basic and translational research institutes and public health centres across Europe with an outstanding track record in public health support with global reach. DURABLE aims to provide high-quality scientific information in record time to support HERA’s decision-making in preparing for and responding to cross-border health threats and assessing the impact of countermeasures.

DURABLE will coordinate a global collaboration, from pathogen detection, evolutionary analysis and threat characterisation, with One Health approach, to data and information collection and sharing, for optimal threat response. DURABLE is a unique multidisciplinary consortium with complementary expertise to meet this challenge and build productive interactions with HERA and other stakeholders.

Due to their outstanding track record and experience in the field, the DURABLE consortium is competent from day one. DURABLE will develop and validate a roadmap for rapid deployment of key countermeasures, test the robustness of the network, and assess key aspects of its emergency mode when simulating or dealing with identified threats. Additionally, DURABLE will focus on long-term sustainability by focusing on capacity building, training the next generation of researchers and developing pandemic preparedness training modules for the network and beyond.

DURABLE website: DURABLE – Improving Europe preparedness and readiness to pandemics (durableproject.org)

DURABLE in figures

 

DURABLE is co-funded by the European Union

 

1. Institut Pasteur (IP) France
1.1 Pasteur Network (PN)

2. Katholieke Universiteit Leuven (KU LEUVEN) Belgium

3. Statens Serum Institut (SSI) Denmark

4. Friedrich Loeffler Institut - Bundesforschungsinstitut fuer Tiergesundheit (FLI) Germany

5. Charite - Universitaetsmedizin Berlin (CHARITE) Germany

6. Erasmus Medisch Centrum Rotterdam (EMC) Netherlands

7. Partikas Drosibas, Dzivnieku Veselibas un Vides Zinatniskais Institutsbior (BIOR) Latvia

8. Universite d’Aix Marseille (AMU) France

9. Rijksinstituut voor Volksgezondheid en Milieu (RIVM) Netherlands

10. Universita Degli Studi di Padova (UNIPD) Italy

11. Uniwersytet Jagiellonski (JU) Poland

12. Agencia Estatal Consejo Superior de Investigaciones Cientificas (CSIC) Spain

13. Helsingin Yliopisto (UH) Finland

14. Aristotelio Panepistimio Thessalonikis (AUTH) Greece

15. Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA) Portugal

16. Univerzita Karlova (CU) Czech Republic

17. Istituto Superiore di Sanità (ISS) Italy

18. Tartu Ulikool (UTARTU) Estonia

19. Hrvatski Zavod za Javno Zdravstvo (CIPH) Croatia

Project objectives

• DURABLE will be a one-stop shop for diagnostics, research, preparedness and response to current and future health threats for the benefit of citizens in the EU and worldwide.
  
  
• DURABLE will establish a sustainable network of laboratories and research institutes that can address the barriers of better preparedness, and provide alerts, real-time scientific data and integrated analyses to HERA.
  
  

• DURABLE will:
   - Develop and use both non-targeted and targeted methods for identification of known and new threats
   - Coordinate, integrate, analyse and share the output for rapid and direct use in public health decision making
   - Develop targeted studies to guide further evidence gathering in response to alerts

Expected results of the Work Packages (WPs)

WP1 - Project management, communication and dissemination

WP1 will develop a joint consortium communication strategy and tools, and a data management plan.

WP2 - Network eco-system modelling

WP2 will deliver a comprehensive model of the lab network structure, a governance and sustainability plan, a stakeholder analysis and KPIs and scenario exercises.

WP3 - Enhancing European and global cooperation

WP3 will map the core network, the links with research consortia and other initiatives, and the extended international network of the individual partners and possible future initiatives.

WP4 - Pro-active identification of pathogens and variants

WP4 will develop a toolbox facilitating the broader surveillance, and prepositioned sampling protocols.

WP5 - Pro-active phenotypic characterization of high-risk animal and emerging pathogens

WP5 will develop new state-of-the-art in vitro and ex-vivo laboratory systems to study virus infections, and new assays to determine phenotypic traits.

WP6 - Continued improvement of countermeasures

WP6 will develop assays and run screening campaigns with 250,000 compounds to identify hits (Hits that block replication are interesting as tool compounds supporting mechanistic studies).

WP7 - Pathogen and outbreak tracking

WP7 will develop and provide a new database, and a new generation of analytical tools for pathogen and outbreak tracking.

WP8 - Forecasting and scenarios

WP8 will develop new mathematical models and a comprehensive analytical framework supporting risk assessments.

WP9 - Validation and deployment of novel diagnostics, genomics and analytical workflows

WP9 will facilitate the rapid roll out of essential assays in case of new discoveries through WP4 or from outside of the consortium.

WP10 - Training and capacity building

WP10 will deliver three Project Schools, webinars and comprehensive training materials.

WP11 - Response to Emergencies

WP11 will develop a protocol for a coordinated response to emergencies.